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Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementiasee WARNINGS AND PRECAUTIONSand Clinical Studies
The WHI Memory StudyWHIMSestrogen-alone ancillary study of WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with daily CE0.625 mgalonerelative to placeboIt is unknown whether this finding applies to younger postmenopausal womensee WARNINGS AND PRECAUTIONSUse In Specific Populationsand Clinical Studies
Additional postmarketing adverse reactions have been reported in patients receiving other forms of hormone therapy.
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there is also some evidence that the equine estrogen contained in premarin may cause cancer.