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Beta BlockersConcomitant therapy with beta-adrenergic blockers and verapamil may result in additive negative effects on heart rateatrioventricular conductionand/or cardiac contractilityThe combination of sustained-release verapamil and beta-adrenergic blocking agents has not been studiedHoweverthere have been reports of excessive bradycardia and AV blockincluding complete heart blockwhen the combination has been used for the treatment of hypertensionFor hypertensive patientsthe risks of combined therapy may outweigh the potential benefitsThe combination should be used only with caution and close monitoring.

Uncommon0.1to 1Elevated liver enzymestransaminasesalkaline phosphataseRef]

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